Primary malignant mucosal melanoma of the maxillofacial area
김현민, 이상훈, 차인호, 김형준, 남웅,
소속 상세정보
김현민 ( Kim Hyoun-Min ) - Yonsei University College of Dentistry Department of Oral and Maxillofacial Surgery
이상훈 ( Lee Sang-Hoon ) - National Cancer Center Research Institute and Hospital Oral Oncology Clinic
차인호 ( Cha In-Ho ) - Yonsei University College of Dentistry Department of Oral and Maxillofacial Surgery
김형준 ( Kim Hyung-Jun ) - Yonsei University College of Dentistry Department of Oral and Maxillofacial Surgery
남웅 ( Nam Woong ) - Yonsei University College of Dentistry Department of Oral and Maxillofacial Surgery
Abstract
Objectives: We aimed to collect and report data from all patients who have been diagnosed with mucosal malignant melanoma to obtain the epidemiology and principles of current treatments.
Materials and Methods: Between January 2008 and December 2018, 20 patients underwent surgery or follow-up observations at Yonsei University Dental Hospital. The patients’ clinical information was reviewed retrospectively.
Results: Seventeen of 20 patients had undergone definitive surgery, while only 6 patients received adjuvant radiotherapy or systemic therapy. Eight of 20 patients, including those that had recurrent lesions, were provided immunotherapy. The 3-year survival for all stages was 50%, with a local recurrence rate of 75% and a metastasis rate of 65%.
Conclusion: The overall survival of patients receiving surgical treatment was longer than that of patients who did not undergo surgical resection. Eight of 20 patients received immunotherapy as the first-line regimen at our clinic, and those patients exhibited longer overall survival compared to patients in reported keynote studies.
키워드
Malignant melanoma; Immunotherapy; Oral cancer
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